Elemental speciation plays an important role in food safety. The determination of the total form of an element only tells part of the story. For example, the toxicity of arsenic is strongly affected by its chemical form. The inorganic forms of arsenic, i.e. arsenite (As (III)) and arsenate (As(V)), are generally more toxic than the organic forms of arsenic (dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA)). In this first study, we report the results obtained from Abbott Nutrition (AN) and UC Davis laboratories for the determination of four arsenic species (As(III), As(V), DMA and MMA) in raw ingredients and milk-based infant formula products using high-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS). The second study, furtheres our speciation study in infant formula products. A simultaneous, fast and sensitive method for the analysis of iodine and bromine species in infant formula was developed using HPLC-ICP-MS. The 4 species of interest were I−, IO3−, Br−, and BrO3− . All 4 species were separated in less than 6.5 min. The limits of detection for I−, IO3−, Br−, and BrO3− were all less than 0.6 mg/ kg respectively. The method was used to determine the four halogen species in a NIST 1849a (Infant/Adult Nutritional Formula) standard reference material and four commercially available infant formula products from the United States and China. To test the suitability of the method for the accurate determination of low concentrations of the four species in infant formula samples, a spike recovery test was carried out at 20 and 40 µg/kg. Total elemental determinations of iodine and bromine were also performed using the triple quadrupole ICP-MS, without HPLC.

Iodine, bromine, and arsenic speciation analysis in infant formulas

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.