Interstrand DNA-DNA cross-links (ICLs) can be generated by endogenous processes, anticancer drugs, and environmental agents.  ICLs prevent strand separation and compromise the function of cellular DNA.  We have characterized a group of ICLs derived from abasic (AP) sites that are common lesions in cellular DNA.  Recent studies revealed that a cross-link derived from the reaction of an AP site with an adenine residue in duplex DNA can be repaired by the base excision repair glycosylase NEIL3.  We will describe chemical and structural features that allow cross-linked DNA duplexes to be unhooked by this novel glycosylase-dependent mechanism.

Unhooking of DNA-DNA interstrand cross-links by the base excision repair glycosylase NEIL3

2019 Fall National Meeting

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