Drug delivery systems increase the therapeutic efficiency of the chemotherapeutic agent by controlling the rate at which the agent is released from the carrier to the systemic circulation or tissues, minimizing its interaction with non-pathological sites. Available delivery systems exhibit high toxicity. However, natural biomaterial polysaccharides are highly stable, non-toxic, hydrophilic, biodegradable, and abundantly available. These polysaccharides also have low processing costs as compared to current lipid-based and protein-based delivery systems. The presence of hydrophilic groups enables them to form non-covalent bonds with biological tissues. This prolongs the residence time, thus increasing the absorbance of the loaded drug. Previous in vivo studies on healthy mice models showed the non- toxic nature of the polysaccharide based delivery system at varying doses. Based on the tissue culture experiments using various cancer cell lines, the selected delivery system showed a better efficiency for the pancreatic cell lines. The present poster expands the in vitro safety/toxicity study to include in vivo mouse models targeting pancreatic cancer treatment. Blood and urine samples will be collected and compared to the previous preliminary mouse experiment. Tissue samples will also be harvested to determine the efficiency of the polysaccharide delivery system to carry the siRNA based therapeutic agents to the pancreatic cells.

In vivo studies on non-toxic polysaccharide based delivery systems for pancreatic chemotherapy treatment using mice models

2019 Fall National Meeting

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