Reactive Oxygen Species (ROS), which are generally come from the metabolic processes consuming the oxygen, contains superoxide free radicals and non-radical molecular. At the low levels, ROS is a cellular signal messenger to sustain the proliferation and differentiation of the cell, while the excess of the ROS disturbs cellular processes by attacking protein, DNA and lipid. It is reported that the proliferation of cancer needs high levels of ROS than normal cells. Base on this observation, we developed an oxidation-sensitive pro-drug termed self-cyclizing reagents which are non-cytotoxic in the reduced state and converted to a toxic molecule when oxidized by ROS, and it could further improve the ROS level in cancer cells to cause DNA damage. Through this way, we could selectively kill cancer cell while the normal cell can be surviving. We also find that the toxicity could be controlled by the oxidative-cyclizing mechanism of the reaction with ROS.<br/>

Reactive oxygen species-activated DNA damage agents to selectively targeting cancer by oxidative-cyclizing

2019 Fall National Meeting

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