The development of a nickel-catalyzed aromatic C−H alkylation with unactivated alkyl halides facilitates the synthesis of diverse fused ring systems. This carbocyclization of simple aromatic substrates is an attractive alternative to traditional polar or radical ring-forming transformations. The present system uses unactivated primary and secondary alkyl bromides and chlorides, while avoiding the use of precious palladium catalysts and more reactive alkyl iodides commonly used in related reactions.

Nickel-catalyzed, ring-forming aromatic C−H alkylations with unactivated alkyl halides

2019 Fall National Meeting

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