Cu2+ supported on acid activated vermiculite is reported as a recyclable heterogeneous catalyst for the Biginelli reaction under ultrasound conditions. Expanded vermiculite was activated by acid treatment, inmersed into a CuCl2 dissolution (adjusted at pH=5.00), filtered and washed with distillated water and dried in an oven at 110°C by 5 hours. The CuO content of the composite was 6.54% ± 0.004 determined by X ray fluorescence (XRF). The catalytic activity of the vermiculite/Cu2+ composite (VA/Cu2) over the Biginelli reaction was evaluated by adding into a reaction tube as follows: 961mg urea (8mmol), 1040mg ethyl acetoacetate(8mmol), 850mg de benzaldehyde (8mmol), 800 mg of the V/Cu2+ (8%molar) and 10mL of solvent (ethanol:acetic acid 1:1), the tube was irradiated in an ultrasound bath by 90 minutes, an 80% yield was obtained with no apparent decrease in five consecutive cycles of the reaction. The Biginelli product was characterized by melting point, FTIR, 13C NMR, 1H NMR and mass spectrometry.

Vermiculite/Cu2+ composite use as heterogeneous catalyst for the Biginelli synthesis

2019 Fall National Meeting

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