Intrinsically disordered proteins (IDPs) can form dynamic large-scale associated states via liquid-liquid phase separation (LLPS) to generate a second protein-dense liquid phase (protein-rich phase), often in the form of droplets. In the protein-rich phase, dynamic intermolecular interactions occur that engender fluidity, however, the molecular interactions driving phase separation are still not clearly understood. This talk will consider coarse-grained models of protein and a coarse-grained water model with varying degrees of cooperativity and directional hydrogen-bonding to understand the origins of LLPS for IDPS.<br/>

Coarse-grained models for liquid-liquid phase separation of intrinsically disordered proteins

2019 Fall National Meeting

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