Cross-chiral RNA polymerase ribozymes with catalytic activity for L-RNA template-directed synthesis of an L-RNA product from 5’ triphosphate trinucleotide building blocks have been obtained from vitro evolution experiments. The ability of these cross-chiral D-RNA enzymes to synthesize both a functional L-RNA product such as a hammerhead ribozyme and their complementary product template strand using riboPCR is explored. Such a process may be significant to the origins of life on the early Earth.

RiboPCR using a cross-chiral RNA polymerase ribozyme

2019 Fall National Meeting

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