Drug delivery technologies have been quickly innovated in the last few decades, especially in aspect of combination with nanotechnology to advance into multifunctional drug carriers, which can accomplish targeting a tumor, delivering therapeutic molecules, imaging and monitoring drug response. Many models were built and tested; still the challenge is at the choice of the appropriate materials and the facilitation of carrier preparation to achieve both safety and efficacy.<br/>This presentation focuses on our recent results in the establishment of multifunctional Au/silk nanoparticles (NPs) for delivery, imaging and targeting in cancer treatment, prepared by a facile co-precipitation method. The synthetic approach is mainly carried out in mild condition with minimizing residues in the final product. Co-precipitation method is proven to be one of the most straightforward methods to incorporate inorganic and organic materials into a hybrid system with controllability of the resulting structure and characteristics. The obtained Au/silk NPs are expected to advance the drug nanocarriers to a multifunctional system with tunable drug release and designable targeting. The research also provides a NP library with diverse structures and properties, which can be used to manipulate the drug delivery performance. The results are discussed in terms of UV-Vis, DLS, XRD, TEM, XPS, and CLSM.

Facile preparation of Au/Silk nanoparticles as a multifunctional drug delivery system

2019 Fall National Meeting

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