The orthogonal miscibility of fluorous phases has been used to drive the formation of discrete peptide and protein assemblies in aqueous solution and in membrane environments. In addition, incorporation of fluorinated compounds on the surface of mammalian cells results in diminished adhesion to extra-cellular matrix (ECM) proteins and presents a strategy for decreasing the metastatic potential of tumor cells. Fluorinated molecules can be expressed in large numbers, upto a billion molecules per cell. Taken together, these studies present a powerful methodology for engineering orthogonal noncovalent behavior in biological systems. Also discussed will be a simple strategy for the design of hundreds of potential clinical agents against obesity and type 2 diabetes.

Modulating noncovalent interactions at cellular interfaces

2019 Fall National Meeting

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