A new manzamenone derivative and four known manzamenones were isolated from the tropical marine sponge Plakortis sp. These compounds exhibited an improved inhibitory effect against the copper-induced LDL oxidation. Among these known compounds, 43-O-methylmanzamenone A has been exposed oxidative conditions such as hydrogen peroxide, mCPBA and primary alkyl amines to give various derivatives. Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data.

Chemical explorations of the manzamenones from the tropical marine sponge, Plakortis sp

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.