Palladium and nickel have long dominated the field of cross-coupling due to the ease with which they participate in oxidative addition and reductive elimination. While there are notable differences in their fundamental reactivity, decades of research have revealed that these two metals are capable of many of the same reactions. In contrast, we have recently found that these reactivity differences can be used cooperatively; allowing palladium and nickel to accomplish together reactions that neither metal is capable of alone. For example, the reductive cross-electrophile coupling of two similar aryl electrophiles to form biaryls, a general cross-Ullman reaction, was reported by our group several years ago. Our latest results on the use of Pd and Ni will be presented, including couplings of aryl triflates with aryl chlorides, the cross-coupling of two different sulfonate esters, the formation of biheteroaryls, and mechanistic studies that shed light on how the two metals exchange ligands.

Multimetallic catalysis with palladium and nickel

2019 Fall National Meeting

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