One of the key strategies to develop our Millamolecular platform is to leverage collaborations with academic research labs to expand the available collection of unnatural amino acids building blocks, to explore new methods for peptide modifications, and to advance new chemistry for bioconjugation. Advancement of these technologies is directed at enabling the discovery of millamolecular drug molecules, conjugates, and PET imaging agents. The academic research community is well positioned to discover new and innovative ways to access unnatural amino acids of high interest, in particular, those previously difficult or elusive to synthesize. In this presentation, we highlight our collaborative efforts that have enabled access to a diverse set of unnatural amino acids designed based on several program needs. The synthesis of these building blocks was achieved leveraging several cutting-edge methodologies, namely Pd-catalyzed C(sp<sup>3</sup>)-H activation and radical enabled C-C cross-coupling reactions, developed under the Bristol-Myers Squibb (BMS) and The Scripps Research Institute (TSRI) collaboration.

Leveraging academic collaborations and expanding the millamolecular chemistry synthetic toolbox

2019 Fall National Meeting

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