Aleutianamine, a new class of pyrroloiminoquinone alkaloid was discovered from <i>Latrunculia austini</i> recovered from a NOAA deep-water exploration of Aleutian Islands. The discovery of aleutianamine was assisted by using molecular ion networking (MoIN) analysis method. Aleutianamine possesses a highly strained multicyclic ring system with multiple heterocycles embedded. The structure of aleutianamine was elucidated with the assistance of spectroscopic analysis including HRMS, NMR, and CD spectrum in conjunction with advanced computational simulation techniques. Aleutianamine displayed potent and selective cytotoxic bioactivity towards pancreatic cancer (PANC-1) cell lines.

Aleutianamine: Architecturally-complex pyrroloiminoquinone alkaloid with selective cytotoxicity toward pancreatic cancer cell lines

2019 Fall National Meeting

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