The Chemicals Management Plan (CMP) is a multi-phase, Government of Canada initiative jointly managed between Health Canada (HC) and Environment and Climate Change Canada (ECCC) dedicated to protecting human health and the environment from chemical risks.  Some substances that required assessment as part of the CMP had limited substance-specific health effects data available, which presented a challenge in assessing the potential risks to human health.  One way to address data gaps is through the use of a ‘read-across’ approach.  Read-across is the methodology where by toxicity test results for one or more chemical(s) are used to predict the critical health effects or endpoints for another chemical that is considered to be similar based upon scientific justification.  In prinicple, read-across can be used to predict physicochemical properties, (eco)toxicity, and persistence and bioaccumulation potential of chemicals, and require a rationale for chemical similarity.  Similarity may be based on a common functional group(s), chemical class(es), carbon chain length range(s), and/or reactivity in chemical or biological processes.<br/><br/>In the past, read-across has been conducted by HC and ECCC on an <i>ad hoc</i> basis by following guidance developed by the OECD in 2014, and by using internal expertise and judgement.  Recent application of the read-across approach to address data gaps in human health screening level risk assessments of existing substances in CMP will be discussed.

Application of a read-across approach to address data gaps in human health screening level risk assessments and the chemicals management plan

2019 Fall National Meeting

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