Pyrazoles and pyrroles are two important biological nitrogen heterocycle motifs and in fact are extensively being used in medicine. Therefore, it’s necessary to find a green and an efficient way to synthesize, particularly under mild condition and with broad function groups tolerance. Herein, we report an easily-synthesized, inexpensive perovskite CsPbBr<sub>3</sub> photocatalyst to catalyze the tandem reaction of α-bromo ketones with hydrazones or enamines to afford different types of 1,3,5-trisubstituted pyrazoles or 2,5-diaryl-substituted pyrroles. Unlike traditional synthesis pathways or molecular photocatalysis, our reactions can process under visible light illumination and in mild conditions (room temperature, open air) with the expected products in good to high yield. Moreover, we also demonstrate a possible pathway for synthesis of Lipitor, a famous cholesterol-controlling drug with the help of our novel perovskite photocatalysis.<br/>

Solar energy induced drug synthesis: Lead-halide perovskite nanocrystals as efficient photocatalysts for N-hetero cyclization reactions

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.