Palladium (Pd) is a well-known efficient homogeneous catalyst for many reactions in organic syntheses. Many of these reactions are required to conduct under high temperature to achieve better reaction efficiency. However, the high temperature of reactions not only have to spend a lot of energy, but also is unfavorable for asymmetric synthesis. Moreover, it is usually difficult to recover this kind of precious metal catalysts. Therefore, an efficient, heterogeneous catalysts photocatalysis function under mild ambient conditions is highly desirable. Herein we report that the Pd-CsPbBr3 photocatalyst that selective growth of Pd NPs on the surface of CsPbBr3 NCs, which strongly absorb light and exhibit high activity for Suzuki-Miyaura coupling reactions. In these photocatalytic reactions, CsPbBr3 not only plays a dominant role in the absorption of light, but also contribute to oxidation cycle; while Pd NPs acts as electron reservoirs which are essential for reductive cycles. Therefore, the intrinsic activity for photocatalyst of Pd NPs is significantly enhanced when growing on the surface of CsPbBr3. Furthermore, several chiral products are synthesized via Pd-CsPbBr3 photocatalyst in cooperation with chiral ligand (R)-BINAP at room temperature. Moreover, an anticancer drug lapatinib has been synthesized in three steps with a 55% overall yield, indicating a highly practical synthetic methodology. Comparing to the high loading, intensity energy consuming, difficult to recycle homogeneous Pd catalyst, our cost-effective, easily-prepared, highly-active and reusable Pd doping CsPbBr3 photocatalyst is an alternative in the photocatalysis of organic reaction. These findings provide a useful green photocatalysis for various organic syntheses driven by visible light.

Pd doping CsPbBr3 hybrid perovskite: Photocatalytic asymmetric Suzuki-Miyaura cross-coupling reactions under visible light irradiation

2019 Fall National Meeting

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