Understanding the fate of pesticides in the environment and their metabolic pathways in different systems is critical to the assessment of the potential exposure and risks to human and ecological systems. During the pesticide discovery and development processes, we aim to identify early and deprioritize those molecules with unfavorable environmental profiles to increase the probability of success in developing sustainable products. To achieve the goal, the Corteva research team have established the approaches integrating in silico tools and high throughput screenings to enable the prediction and selection of environment-friendly molecules at early Discovery phases. The high throughput 30 day soil degradation, soil sorption, and rat liver microsome stability assay were developed in 96-well plate as the first tier screening. In conjunction with the in silico prediction tools it enables quick identification of molecules with potential persistence, leaching or bioaccumulation issues from a large pool of analogs. Comparing to the traditional study design, it significantly improves the throughput, reduces the cycle time and resource needs while providing accurate predictions for decision making.

High throughput environmental fate and metabolism assays to support pesticide discovery & development

2019 Fall National Meeting

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