An innovative molecular imprinting approach was developed for the determination of newly FDA approved antiviral drug, sofosbuvir (SOF). The method based on polymerization of ρ-aminothiophenol (ρ-ATP) on S, N co-doped graphene quantum dots in presence of gold nanoparticles to form Au-S covalent network. The presence of quantum dots improved the electron transfer rate, enhanced surface activity and amplified the peak signal. The synthesized nanocomposites were described by FTIR, TEM, EDX, SEM, and techniques. The electrochemical features of our fabricated sensor were (scanned) by differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The proposed sensor was applied for the determination of SOF indirectly by inhibition the influx of redox probe into the SOF specific sites. The linear range of the fabricated sensor towards SOF analysis was from 0.1 to 40.0×10-8M with LOD of 0.036 ×10-8M. The sensor has shown several merits such as high selectivity, ultra-sensitivity, reproducibility and stability. Moreover, the sensor was used for the analysis of SOF in complexed matrices as human plasma.

Decoration of S,N co-doped graphene quantum dots with ρ-aminothiophenol functionalized AuNPs for molecular imprinted sensing of sofosbuvir in real samples

2019 Fall National Meeting

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