Liposomal nanoparticles are essential in the delivery of chemotherapeutic drugs in the treatment of multiple myeloma cancer. The development of an ideal liposomal nanoparticle drug delivery system is of increasing interest to ensure that the conjugated drug carrier complex arrives and acts preferentially at the tumor site with high efficacy and lower toxicity. The focus of this work lies in the synthesis of biopolymer functionalized multilamellar (MLV) vesicles to enhance the stability and bio adhesivity of the liposomal nanoparticle system. Characterization of the liposome vehicles were studied using Fourier Transform Infrared Spectroscopy (FTIR), zeta potential analysis, particle size analysis (PSA), and scanning electron microcopy (SEM). Preliminary findings in the characterization of the synthesized liposomes using FTIR showed characteristic symmetric and antisymmetric CH2 (at 2,800–3,000 cm−1) bands and the C=O (at 1,740 cm−1) stretching bands attributed to the presence of chitosan on the liposome surface. Structural characteristics of the synthesized liposomes were also studied by dynamic light scattering. The liposome suspensions presented exhibited mean diameters between 150 nm and 250 nm, polydispersity indexes (PDI) around 0.4, zeta potential values between -40 mV and -30 mV, indicating complex formation between the anionic liposomes and cationic chitosan molecules. The surface morphology of the scaffolds were studied using scanning electron microscopy (SEM) and it was observed that the liposomes are uniform in diameter (~190nm) with multilamellar structures. XRD analysis exhibited diffraction peaks corresponding to chitosan functionalization occurring at 20°2. Stability studies of the functionalized CS-liposomes showed increased stability to aggregation than pristine liposomes when stored at ambient temperatures. The development of chitosan functionalized liposomal nanoparticle drug delivery systems (DDS) shows great promise in the delivery of anticancer drugs, through the reduction/elimination of toxic and adverse effects resulting from their administration.

Biopolymer functionalized liposomes for enhanced dispersion stability of nano vesicles

2019 Fall National Meeting

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