A recent resurgence in methods to synthesise sulfur(VI) compounds have blossomed due to their fascinating medicinal and structural properties. For example, sulfoximines have been shown to be potent and selective kinase inhibitors, as well as having improved solubility and pharmacokinetic properties over other similar functional groups. Sulfur(VI) also allows the introduction of a new chiral center and thus the formation of interesting bioisosteres and cyclic drug molecules. This work explores the use of both chiral and achiral sulfonimidates to synthesise a plethora of sulfoximines and sulfonamides, with the goal of developing novel methodology for the introduction of sulfur(VI) into drug scaffolds. There is particular emphasis on exploring sustainable and catalytic methods.<br/>

Exploring the reactivity of sulfur(VI) via sulfonimidate intermediates

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.