The expectation that herbicides will consistently contribute to yield increases in crop production into the future is under threat from the rise in the number of resistant weed species and a lack of choice of new active ingredients. After a long interval of no new herbicide mechanisms being identified, we can report that aryl pyrrolidinone anilide compounds are potent and selective herbicides with novel mode of action. We have identified dihydroorotate dehydrogenase, the enzyme catalyzing the fourth step in de novo pyrimidine biosynthesis as the target of these molecules. Furthermore, the basis of the selectivity of the chemistry is at least partially determined by the nature of the interaction of the compounds at the enzyme active site.<br/>

Inhibition of a step in plant <i>de novo</i> pyrimidine biosynthesis by a new class of herbicide causes selective phytotoxicity with commercial levels of activity

2019 Fall National Meeting

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Inhibition of a step in plant de novo pyrimidine biosynthesis by a new class of herbicide causes selective phytotoxicity with commercial levels of activity