Recent advances in catalysis have helped CO2 realise its potential as a cheap, abundant C1 source in reductive cross-coupling reactions. Many of these developments eliminate the need for harsh oxidants or organometallic reagents. However, despite this recent progress there remains a dearth of methods for direct enantioselective carboxylation. Coupled with the prevalence of carboxylic acids in active pharmaceuticals such as (S)-Naproxen (1), development of a robust asymmetric carboxylation remains a synthetic challenge of great importance. A range of bis(oxazoline) ligands were synthesised and tested in the regio- and enantioselective carboxylation of allyl esters. Results to date on this project will be presented.

Development of a metal-catalysed asymmetric carboxylation

2019 Fall National Meeting

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