With the emergence of severe fungicide resistance in crop protection, and the increasing morbidity and mortality of fungal infections due to drug-resistance in human health, novel antifungal agents with new mode-of-action are urgently needed. After screening the boron-containing chemical library at Boragen, we discovered a novel series of boron-containing compounds showing good antifungal activity. An in-depth structure−antifungal activity relationship was carried out, and we identified compounds with broad spectrum antifungal activities. This study demonstrates that the novel boron-containing compounds disclosed herein have significant potential as antifungals agents.

Novel boron-enhanced compounds with broad spectrum antifungal activity

2019 Fall National Meeting

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