Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, including anti-inflammatory, anti-carcinogenic and anti-atherogenic properties. There is increasing interest in the exploration of health beneficial properties of PMFs in citrus fruits.  We will discuss the extensive metabolism of PMF by gut microbiota as well as in liver. Tissue distribution indicates that PMF can penetrate blood-brain-barrier and exists in brain tissue in relatively high concentration. Recent research on anti-obesity effects and mechanism of PMF will be reviewed, particularly on their interaction with gut micobiota. PMF have strong prebiotic effect as indicated by the elevated production of short chain fatty acids and the bloom of Lactobacillus and Bifidobacterium in the high fat diet-induced obese mice. Moreover, the inhibition of PMF on Acetatifactor and Bilophila suggested that the fat-bile-gut interaction may contribute to the anti-obesity of PMFs.

Polymethoxyflavones from citrus: Chemistry, metabolism and selected bioactivity

2019 Fall National Meeting

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