Dietary elements and its resulting metabolites have influential role in shaping the microbiota, which has paramount impact on host associated metabolic disorders.  Consumption of high fat diet (HFD) has detrimental effects in deteriorating the host system with dysbiosis in the gut microbial community. Intervening such metabolic abnormalities with pre- or pro-biotics is emanating as a topic of current interest, since the world has started to highly rely on westernized diet having bountiful supply of fat. Herein this study, we have investigated the effect of mushroom derived β-glucan, a highly soluble dietary fiber, on high fat diet induced obesity and the associated gut microbial imbalances. Apart from inducing anti-obesity nature, β-glucan consumption adds bulk to stool with faster intestinal transit rate (p&lt;0.05) thereby relieving high fat diet induced colonic motility disorder such as constipation. Further, β-glucan intake ameliorates high fat induced stress condition on liver in addition to restoration of intestinal architecture with enhanced expression of tight and adherent junctions. The reduction in goblet cell counts with the consumption of high fat and thus mucin production has been reverted to normal with the inclusion of β-glucan in the diet. More importantly, favourable shift in the gut microfloral community with the β-glucan uptake suppresses the adverse effects of high fat diet consumption. Altogether, the outcomes of the present study indicate that the β-glucan can be used as a promising therapeutic prebiotic in alleviating the high fat diet induced metabolic disorders.

Long-term impact of mushroom derived β-glucan on obesity and gut microflora in mice fed with high fat diet

2019 Fall National Meeting

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