Florylpicoxamid is a novel picolinamide from Corteva Agriscience for fungal disease control. Inspired by the natural product UK-2A, the design of florylpicoxamid focused on retaining structural features critical to binding at the ubiquinone Qi target site of mitochodrial complex III. It displays market-leading control of wheat leaf blotch and other commercially important diseases in many crops. The structure-activity relationship (SAR) studies leading to the discovery of florylpicoxamid and other biological characteristics will be reviewed.

Discovery of florylpicoxamid, a new picolinamide for disease control

2019 Fall National Meeting

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