The avicide 3-chloro-4-methylanaline hydrochloride (chloro-p-toluidine hydrochloride, CPTH, DRC-1339) is used to reduce damage to crops caused by pest bird species.  CPTH is a nephrotoxin which causes significant damage to the proximal convoluted tubules of exposed birds.  Necrosis suggests that formation of a highly reactive CPTH metabolite was responsible.  Specifically, damage could be due to the formation of a tissue adduct with CPTH.  In an attempt to identify this metabolite, red-winged blackbirds were dosed with CPTH and their kidneys subjected to both a proteomic and metabolomic assays using LC-QTOF mass spectrometry.  The proteomic results were inconclusive and did not demonstrate any protein adducts.  However, the metabolomic assay did shed new light on the physiological effects of CPTH.  In addition to two previously known metabolites of CPTH, six new metabolites were identified.<br/>

Using metabolomics to provide evidence of a reactive metabolite of an avicide

2019 Fall National Meeting

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