Concentrations of urine component are widely used in disease detection and health management. However, they are influenced by the amount of urine. The urine creatinine is hardly affected by urinary variation factor. Therefore, the amount of urine component can be estimated as the value per gram of creatinine. The method for simply measuring the amount of urine creatinine is required. Recently, the scheme for the creatinine detection based on the formation of a soluble copper-creatinine complex on the copper electrode surface has been studied. However, in previous report, liner range is narrow, and it was necessary to dilute the urine for measurement. In addition, uric acid has been reported to be an interferent, this effect must be removed. In this study, we developed an electrochemical sensor that can detect creatinine concentration using the collected urine as it is without being affected by uric acid. It is reported that Nafion removes the influence of uric acid. The concentration of Nafion solution applied to the electrode was optimized so that it could be used for the collected urine itself. In order to raise the detection limit concentration of creatinine, the electrodeposition time of copper was extended. Finally, we succeeded in creating a sensor that detects the amount of creatinine from the collected urine itself.

Improvement of a sensor for urine creatinine using a copper electrodeposited gold electrode

2019 Fall National Meeting

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