Our lab has developed synthetic methods that allow a robust variety of modifications to the thioether containing side-chains in methionine residues. One modification is the mild oxidation of hydrophobic, alpha-helical poly(methionine) to hydrophilic, conformationally disordered poly(methionine sulfoxide). This polymer was found to possess non-fouling properties similar to PEG, but is also degradable and capable of being reduced back to methionine within cells. We report on the development of self-assembled biomaterials, such as vesicles and hydrogels, incorporating poly(methionine sulfoxide) as the solvent exposed hydrophilic segments. The use of these finely tuned hydrogel formulations for study of central nervous system biology will be presented.

Use of poly(methionine sulfoxide) to impart cell and tissue compatibility in degradable biomaterials

2019 Fall National Meeting

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