Cell mechanics plays an important role in many essential biological activities, including cell migration, differentiation, wound healing, and tissue integrity. Recent studies suggest that after being exposed to a variety types of nanoparticles, cells show short-term to long-term abnormalities in their mechanical behaviors. So far, there is little evidence on the mechanisms that cause the mechanical behavior abnormalities. It is largely unclear whether the nanoparticles interfere with the cell mechanic system directly through the interaction with the cytoskeleton protein molecules, or profoundly through the interference with the cell gene translation and protein expressions, or perhaps both. Our recent efforts investigate the impact of nanoparticles on cell mechanics, that is bio-nano-mechanics. We have developed single particle tracking techniques with gold nanoparticles. Using these imaging tools, we study the intracellular transport of nanoparticle cargos and the interference of the diagnostic/therapeutic nanoparticle probes to the cytoskeleton and cell motility. <br/>

Biophysical and bio-nano-mechanical insights from tracking single gold nanoparticles in live cells

2019 Fall National Meeting

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