Protein crowding near membrane surfaces is unavoidable in cellular environments. Results from molecular dynamics simulations suggest that concentrated protein solutions in the presence of membranes prefer increased clustering instead of interactions with the membrane surface suggesting preferential solvation of membrane surfaces vs. proteins. An analysis of solvent properties near membrane surfaces with and without protein crowders is presented to provide insights into the balance between membrane, protein, and solvent interactions in such complex systems.<br/>

Preferential solvation of membrane surfaces in the presence of protein crowders

2019 Fall National Meeting

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