Numerous research efforts have been made on developing highly sensitive biosensing platforms incorporating metallic and non-metallic nanoparticles featuring superb optical and electrochemical properties in addition to high surface volume ratio for a wide spectrum of applications.1 In this talk, I will highlight some of our recent efforts on the creating highly sensitive and selective biosensing platforms employing various sizes and shapes of mostly gold and carbon nanoparticles in conjunction with surface bioaffinity interactions for biomedical applications. Two key compartments were integrated into our surface sandwich biosensing platforms with either optical or electrochemical detection methods; the use of a pair of bioreceptors involving antibody-aptamer or aptamer-aptamer for a targeted protein biomarker with surface enzyme reaction usually improved the selectivity, while the gold or silver or carbon nanoparticles conjugated with one of the bioreceptor molecules enhanced the sensitivity. Examples of targeted protein biomarkers for potential diagnostic applications are tau 381, alpha-1-antitrypsin, B-type natriuretic peptide and avian influenza and norovirus proteins as well as small molecular weight molecules.2-4 Our latest developments on paper chip based immunoassay platforms with antibody conjugated carbon nanoparticles and surface sandwich bioaffinity complex formation will also be introduced for potential biomedical applications. Lastly, I will address remarks on future aspects and challenging issues for our nanoparticle integrated biosensing methodologies.

Better analysis for proteins with metallic and non-metallic nanoparticle-integrated biosensing platforms

2019 Fall National Meeting

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