The straightforward [JB1] and reproducible preparation of defined functional nanostructures still remains a challenge in materials science. Combining a one-pot sequential RAFT polymerization with the polymerization-induced self-assembly (PISA) not only facilitates access to reproducible block copolymers, as they are solely defined by the applied starting materials, but also governs the repeatable formation of uniform self-assembly morphologies. Moreover, the micellar structure can be tuned by modifying the key parameters of the polymerization, i.e. molar mass, temperature, concentration, polymer and solvent composition. In consequence, a variety of morphologies become accessible including short, long, and branched filomicelles, as well as vesicles of different sizes. With introduction of new monomers based on thioethers, we further developed materials, which react upon external stimuli. The resulting micelles or vesicles further enable the encapsulation of either hydrophobic or hydrophilic materials, respectively, which can be released in oxidative environments (Figure 1).[1] These oxidation processes can either be induced by light, using Ru-complexes, or even by biological processes, as they are present in activated immune cells.[2] In summary, our new systems combine the advantage of reproducible polymer and nanostructure formation with functionality.

One-pot synthesis of functional micelles and vesicles

2019 Fall National Meeting

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