It has been demonstrated that diabetes is related to abnormal sugar levels in human body. Thus, rapid and sensitive determination of glucose in biofluids is of great importance for managing insulin administration. While, low concentration and complicated interference analysis restrain the development of noninvasive detection of glucose in practical applications. In this work, a sensitive and selective Glu sensor was constructed by modifying gold-decorated glass nanopore with smart polymers, which was achieved by a facile and controllable method through Au-S bonding. The copolymer chains displayed an obvious conformational transition from a collapsed state to a stretched one via the synergetic hydrogen bonding interactions, accompanied by significant changes in wettability. Based on this feature, the recognition of glucose can be transduced into the electrochemical signal change. The results show that our proposed electrochemical method exhibits unique specificity toward glucose among interfering materials such as cysteine, vitamin C, uric acid, urea. Moreover, it has a detection limit of 1 nM, meeting the demand in practical determination process. Most importantly, this proposed work unveils a novel and effective platform for monitoring glucose in saliva, and shows great promises in broad applications in controllable drug carries, microfluidic chips involved physiological and pathological events.<br/><br/>

Functionalized nanopore biosensor for quick and highly sensitive glucose detection in human saliva

2019 Fall National Meeting

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