Stimuli-responsive polymers that respond to internal or external stimuli have emerged as an effective approach for selective drug release at target disease sites. Among them, thermo-responsive drug carriers that can release drugs are promising for selective drug release in the target areas. In this study, thermo-responsive and biocompatible poly(<i>N</i>-vinyl caprolactam) (PVCL)-based drug carriers were synthesized via stop-flow lithography (SFL). The PVCL-based particles showed a sharp volume phase transition temperature (VPTT) close to body temperature. The VPTT of the PVCL-based particles can be adjusted to vary from room temperature to body temperature by tailoring their monomer compositions during the fabrication. To achieve thermo-responsive drug delivery, doxorubicin (DOX) was encapsulated into the PVCL particles as an anticancer drug. The DOX-loaded PVCL particles exhibited thermo-responsive drug release and consequent anticancer activity in cancer cells. Importantly, PVCL-based particles showed high biocompatibility. This study demonstrates that thermo-responsive PVCL particles are biocompatible and efficient drug carriers for anticancer therapy.

Thermo-responsive poly(<i>N</i>-vinyl caprolactam) (PVCL)-based drug carriers for controlled drug release

2019 Fall National Meeting

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Thermo-responsive poly(N-vinyl caprolactam) (PVCL)-based drug carriers for controlled drug release