Tetracyclines are the most frequently used among veterinary antibiotics. In Korea, usage of tetracyclines is shared approximately 30 to 50% of the total antimicrobial consumption during 2003-2012. In this study, ferrate(VI) was used to degrade tetracycline in the water phase. ferrate(VI), the red-purple colored 6+ iron (FeO42-), is a kind of strong oxidant. And because Fe(III), the by-product of ferrate(VI) is non-toxic, so ferrate(VI) is regarded as an environmental-friendly oxidant. This study aims to observe the degradation efficiency of tetracycline by ferrate(VI), and finally determine the optimal condition. Ferrate(VI) was synthesized by US Patent 8,961,921,B2. The 10 ppm of tetracycline solution was prepared in pH 7 phosphate buffer solution. The tetracycline solution was put in the glass reactor. The temperature in all experiments was set to 20<sup>o</sup>C. After adjusting with ferrate(VI), 5 mL of samples were put in the vial with 5 mM of sodium thiosulfate solution and filtered with 0.45 μm of nylon syringe filter. The extracts were analyzed by a Shimazu HPLC (Shimazu, Japan) with a diode array detector(DAD). The DAD wavelength for detection was set at 350 nm.<br/>The degradation efficiencies of tetracycline with ferrate(VI) dosages of 6.4 μM, 12.8 μM, 31.9 μM, and 63.8 μM are shown by Fig. 1. The results with ferrate(VI) dosage of 31.9 μM and 63.8 μM were above 99% within 15 seconds. And, the degradation efficiency was approximately 53% at 6.4 μM of ferrate(VI) dosage. By referring to other studies, NH2=O group in tetracycline was modified or removed. Many studies have shown that ferrate(VI) could treat effectively nitrogen- and sulfur-containing compounds, it is estimated that NH2=O of tetracycline reacted rapidly within 15 seconds. The research of degradation of tetracycline by ferrate(VI) is under investigation, additionally, the different water condition such as pH and water temperature also would be considered.

Degradation of tetracycline by ferrate(VI): Reaction kinetics and efficiency evaluation

2019 Fall National Meeting

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