Carbon monoxide (CO) is a colorless and odorless gas is endogenously produced through catabolism of heme oxygenase (HO). Despite the notoriety as the “silent killer” at high concentration, CO has recently been in the spotlight for its promising potential as a medical gas in clinical applications such as organ transplantation and wound healing etc. Several methodologies have been adopted for designing an efficient CO delivery, which include mixing of CO with breathing air as well as using CO releasing moieties(CORMs) based on transition metal carbonyl complexes(MCCs) for use as pro-drugs. Till to date, photoCORMs have been introduced in various macromolecular and inorganic CO-releasing vehicles for CO-release. All of these inorganic and polymeric CO-releasing carriers are alternative to CORMs which release potentially toxic metal fragments, cannot be use in antibacterial or wound- healing bandage applications due to their non-substantial physical appearance, as well as they require decorative and time-consuming fabrication methods and needed UV-light irradiation for CO-release. To overcome these drawbacks, we designed and synthesized a green light triggered CO-releasing polymer (CORP) via ring opening metathesis polymerization (ROMP). CORP is stable and releases CO with dual response like colorimetric and fluorometric.

Light-responsive CO-release from polymer synthesized via ring opening metathesis polymerization (ROMP)

2019 Fall National Meeting

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