The use of human growth hormone (HGH) and other banned steroids to increase athletic performance in competitive sports is an ever-growing concern that requires a more efficient detection system. Current detection methods work by testing the blood of an individual, which requires off-site specialized equipment and prolonged procedures. A more efficient system that still maintained high sensitivity and selectivity will provide results that can be used on-site by sporting officials, coaches, and regulatory agencies. Our research group has previously developed sensors for analytes using cyclodextrin as a supramolecular scaffold to promote favorable interactions between analytes of interest and high quantum yield fluorophores or dyes as detectors. Reported herein is our work on using cyclodextrin-based systems to detect HGH and other analytes that are of interest in illegal doping scandals, including steroids and HGH metabolites by combining those analytes with a  color-changing dye that rapidly responds to the presence of the analyte with measurable changes in color. This system operates with high sensitivity and selectivity in solution-based testing, and efforts to apply the system in solid-state devices are currently in progress.<br/>

Detection of steroids and human growth hormone using color-changing cyclodextrin systems

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.