Nanotechnology-based medicine (Nanomedicine) has received progressive interest for the treatment of intractable diseases, such as cancer. Engineered polymeric nanosystems with smart functions play a key role in nanomedicine as drug carriers, gene vectors, and imaging probes. This presentation focuses present status and future trends of the development of polymeric micelles with distinctive core-shell architecture as self-assembled nanosystems with 10 to 100 nm in size prepared by the programmed self-assembly of block copolymers in aqueous entity. Several micellar formulations of antitumor drugs have been intensively studied in preclinical and clinical trials, and their utility has been demonstrated. Critical features of the polymeric micelles as drug carriers, including particle size, stability, and loading capacity and release kinetics of drugs, can be modulated by the structures and physicochemical properties of the constituent block copolymers. The development of smart polymeric micelles that dynamically change their properties due to sensitivity to chemical or physical stimuli is the most promising trend toward nanomedicines, directing to the targeting therapy with high efficacy and ensured safety. Notable anti-tumor efficacy against intractable cancer, including pancreatic cancer and glioblastoma, of antitumor drug-incorporated polymeric micelles will be demonstrated to emphasize a promising utility of the nanosystems for the treatment of intractable diseases.

Self-assembled supramolecular nanosystems for smart targeted therapy of cancer

2019 Fall National Meeting

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