Green synthesis of polymeric biodegradable nano- or microparticles has drawn increasing attention in the field of medicine as drug delivery system (DDS) since it has the ability to transport drugs with the minimal but optimum dosage. Starch, a major source of carbohydrates from plants are biocompatible material, that can be utilized as DDS but its molecular self-assembly results in a highly aggregated and polydisperse particles limiting its biomedical applications. However, green methods for fabrication of starch nano- or microparticles often lead to difficulty in insuring the monodispersity of formed particles with respect to size and shape, which is an important criterion as DDS. In this study, monodisperse starch nano- or maicroparticles (SPs), in combination with chitosan, a cationic polymer that effects as polymeric stabilizer, were fabricated via molecular self-assembly using short chain glucans which were enzymatically obtained from waxy maize starch. We found that chitosan mediates the particle formation via electrostatic interaction, which rendered an effective separation of homogenous nucleation and growth of SPs, eventually leading to the formation of monodispersed SPs and increased product yield over 70% from natural starch. By modulating the enzyme concentration and debranching time, we were able to prepare a highly monodisperse CS-SPs from 200 nm to 5 μm. Furthermore, the potential of CS-SPs as a carrier system form oral delivery of bioactive compounds were demonstrated using model guest molecules, which is ideal for drug carriers targeting the negatively charged gastric epithelial lining for better bioabsorption since CS-SPs showed a net positive surface charge.<br/>

Molecular self-assembly of chitosan/starch-based nanoparticles for drug delivery system

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.