Ziziphus jujuba Mill., belonging to the Rhamnaceae family, is native to China. The earliest cultivation and domestication of Z. jujuba could be dated back 4000 years along the Yellow River Canyon in the North Shaanxi and Shanxi Provinces of China. Thus, this area is usually considered as the origin center of Z. jujuba. Nowadays, Z. jujuba spreads out in Europe, southern and eastern Asia, as well as Australia. Its fruits also called hongzao in Chinese, is commonly used as food and has been used in Chinese folk medicine for the treatment of fatigue, anorexia and other health problems. In addition, the seeds, bark, roots and leaves of Z. jujuba can also be used as medicine. Jujube leaves have also been used as a commercial herbal tea for its capacity to improve sleep. Thus, bioactive constituents and quantitative analysis of Z. jujuba resources from China were studied. Our results are as follows: 1）Twenty-seven known compounds were isolated and identified as the main constituents from fruits of Z. jujuba, including triterpenic acids, polyphenols and flavonoids, triterpenic acids and flavonoids had strong growth inhibitory effects on human tumor cell lines (MCF-7, A549, HepG2 and HT-29). 2）The EtOH-water extract of Z. jujuba leaves significantly alleviated liver damage induced by CCl4, a quantitative analysis of fifteen major constituents of the bioactive extract was conducted by HPLC-DAD. 3）A validated HPLC-DAD was applied to the simultaneous characterization and quantification of sixteen main constituents in thirty samples, which comprised the whole life stage of Z. jujuba leaves from six cultivars in Yulin, Shannxi Province, China. 4）Triterpenic acids, polyphenols, flavonoids and steroids were isolated and identified from the flowers, seeds and roots of Z. jujuba. Some of these compounds showed hepatoprotective activity and acetylcholinesterase, α-glucosidase, tyrosinase inhibitory activity. Contents of the bioactive constituents from different parts of Z. jujuba were analyzed by HPLC-DAD method.

Phytochemical investigation, biological assessment, and quantitative analysis of Ziziphus jujuba resources from China

2019 Fall National Meeting

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