<br/>Honey, a natural food of nutritional and medicinal value, has been favored by consumers in recent years. Concerning the recent researches about honey, the majority of them have concentrated on the biological functions of polyphenols, such as improving carcinogenesis, aging and atherosclerosis associated with oxidative stress, but there are virtually no reports about the effect of honey at the metabolic level. Based on the identification of honey extracted polyphenols (HEP) and the confirmation of serum antioxidant capacity, this study was dedicated to investigate the metabolite changes in the serum of HEP-intake rats by using an UHPLC-Orbitrap-HRMS based metabolomics approach. The results showed that metabolites in the serum of rats administered HEP differed from those gavaged with distilled water alone. Twenty-nine compounds were identified as discriminating metabolites. All of these compounds involved in five metabolic pathways altered after the intake of HEP, which were related to oxidative stress, inflammation regulation and immune response. The correlation analysis indicated that HEP improve antioxidant capacity in serum, which were relative to discriminating metabolites. The metabolome of rats and associated metabolic pathways were significant altered after the intake of honey extracted polyphenols. The alteration of metabolome may be responsible for the increased serum antioxidant capacity, which may conduce to studying the biological functions and emerging health benefits of honey.<br/>

Effects of honey extracted polyphenols on serum antioxidant capacity and metabolic phenotype

2019 Fall National Meeting

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