While amphibians regenerate lost appendages spontaneously, mammals generally scar over the injury site via wound repair. Inspired by the spontaneous healing trait of amphibians, we are developing self-assembling polymer prodrugs for delivery of a HIF1a agonist. The polymers self-assemble into supramolecular nanostructures, driven by the hydrophobic nature of the conjugated drug. Subcutaneous injection of drug-hydrogel resulted in enhanced regenerative wound healing in non-regenerative mice, in a manner that emulates the basic elements of amphibian regeneration. These approaches offer new opportunities for delivery of tissue regenerative therapeutic drugs.<br/>

Supramolecular polymer prodrugs for drug-induced tissue regeneration

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.