DNA-encoded libraries of small molecules have emerged as efficient tools for the identification of hit-matter in the early phases of drug discovery. However most published libraries, owing to the synthetic restrictions of DNA being present, have low scaffold diversity – both within a given DEL and when compared to existing screening collections.<br/> <br/>To address low scaffold diversity a synthetic route leveraging stereospecific CH arylation of cyclic amino acids was used to access all stereoisomers of the resulting trifunctional compounds. The Fmoc amino acids resulting from this synthesis have been linked to DNA and elaborated into a DEL of 520,800 compounds.<br/> <br/>This talk will cover aspects of synthetic optimization on and off DNA, as well as library validation and early screening results against targets of interest.

Encoding all stereoisomers of homologous cyclic β-aryl amino acids

2019 Fall National Meeting

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