This study investigated the effect of dietary gypenosides on obesity and insulin resistance in male C57BL/6J mice induced by feeding a high-fat diet (HFD). Oral gypenosides administration prevented or reversed HFD-induced obesity and insulin resistance in C57BL/6J mice, without affecting their food intake. Treatment with 300 mg/kg BW/d gypenosides could significantly reduce body weight gain, total plasma cholesterol and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index compared with the control. Moreover, gypenosides consumption alleviated insulin resistance possibly by promoting energy expenditure which upregulating thermogenic genes in the brown and inguinal white adipocyte tissues. In addition, gypenosides administration alleviated gut dysbiosis which accompanied by decreased the ratio of Firmicutes to Bacteroidetes and increased Akkermansia muciniphila abundance in the gut microbiota. The results suggest the health benefits of gypenosides intake in obese mice.

Gypenosides prevent obesity and insulin resistance in C57BL/6J mice by improving thermogenesis in association with alleviating gut dysbiosis

2019 Fall National Meeting

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