Aryl amines are omnipresent in many natural products and it is widely used in many fields like catalysis, polymer, pharmaceuticals, etc. Classical ways to construct an aryl amine bond are 1. Nitration followed by reduction, 2. Ullmann-Goldberg coupling, 3. Buchwald-Hartwig coupling. Whereas, transition metal catalyzed directed C-H amination is a distinguished approach which can bypass the need of pre-activated substrates such as aryl halides. Here we report a new catalytic method for the construction of carbon-nitrogen bond through chelation under mild conditions. The presentation will include details of screening processes for transition metal catalyst, ligands and additives, solvent conditions and substrate scopes. The Reaction mechanism of this catalytic method will also be discussed.

Chelation-assisted decarboxylative amidation

2019 Fall National Meeting

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