Poly(2-oxazoline) and poly(2-oxazine) based micelles show a highly divers and structure-sensitive solubilization behavior for hydrophobic molecules and drugs. Notably, these systems seem to strongly contradict the common wisdom, like-dissolves-like. In fact, the polymers with a minimal hydrophilic/hydrophobic contrast are much typically found to be more successful in solubilizing molecules of ultra-low water solubility. In addition, the hydrophilic corona can exert a significant influence on the drug loading and formulation stability. Our results show that the interactions between polymer and drug which govern drug encapsulation and formulation stability are much more complex than previously thought.

Effects of the polymer corona on the drug loading in ultra-high drug loaded poly(2-oxazoline)/poly(2-oxazine) micelles

2019 Fall National Meeting

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