Supramolecular assembly is fundamental and essential factor of living system. They form defined arrays of high-ordered nanostructures through this process. From self-assembly, they have different size, structure and functions from unit molecule. There have been many research about designing structure by using the self-assembly system of building block that exist in nature, DNA, peptide, lipid and so on. Although much significant advancements in constructing hierarchical structures with these building blocks have been achieved, Peptides are still considered challenging. Because peptides are assembled by the energy ensemble of themselves. Thus, they are difficult to make diverse binding site and design the three dimensional structure. To address this issue, we demonstrate a novel modular approach of self-assembling peptide nanostructure using coiled-coil peptide building block with chemical moieties. To design various types of nano-peptide building blocks, Coiled-coil peptides of various lengths were introduced. Each heterodimeric parallel and antiparallel coiled coil peptides are conjugated with multivalent chemical building blocks strategically. Self-assembly of the peptide building blocks is induced by an annealing process to achieve thermodynamic stability. The morphology of self-assembled peptide building blocks is experimentally shown like a buckyball, closely packed coiled-coil peptide spheres of which each building blocks form a hexagonal network. Most notably, the pore size and dimension of multi-hierarchical peptide nanostructure can be modulated by a combination of different peptide building blocks. We expect that modular approach will provide the basis for construction of multivalent peptide assembly and bring a potential to apply in chemical and biological process.<br/>

Hierarchical supramolecular structure design by chemical-induced self-assembling peptide building blocks

2019 Fall National Meeting

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