Anguidine, and other related trichothecenes, have been actively pursued due to their varied biological activities that depend on the respective functional groups on the tricyclic backbone.  Anguidine itself has been shown to inhibit the initiation of protein synthesis resulting in the death of rapidly proliferating cells such as tumors. Furthermore, anguidine has also been shown to have good antibacterial, antifungal and insecticidal. There have been previous studies to develop an enantioselective synthesis of anguidine and anguidine precursors. Herein, we propose a novel, practical approach using Stork enamine alkylation, followed an aldol condensation and acid-catalyzed intramolecular cyclization. We expect to explore and investigate the functional variety of anguidine to establish an activity profile across a panel of multidrug resistant bacteria. <br/>

Studies towards the total synthesis of anguidine

2019 Fall National Meeting

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